The goal of this research project is to characterize the functional heterogeneity of cord blood-derived normal stem and progenitor cells, synthetic leukemias, and primary specimens, to identify the cell of origin of leukemias and AML/AMKL-specific functional dependencies and genetic vulnerabilities.
This project relies on bulk and single-cell RNA sequencing, in addition to in vitro and in vivo functional assays
Funding: Richard and Edith Strauss Foundation, B.T. Wilhelm and S. Cellot co-lead PI, 2019-2022.
Sonia Cellot Laboratory 